APOBEC3 as a driver of genetic intratumor heterogeneity

Venkatesan, Subramanian; Angelova, Mihaela; Bartkova, Jirina; Bakhoum, Samuel F; Bartek, Jiri; Kanu, Nnennaya; Swanton, Charles

doi:10.25418/crick.24806016.v1

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APOBEC3 as a driver of genetic intratumor heterogeneity

journal contribution

posted on 2023-12-14, 11:19 authored by Subramanian Venkatesan, Mihaela Angelova, Jirina Bartkova, Samuel F Bakhoum, Jiri Bartek, Nnennaya Kanu, Charles Swanton

Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.