The Francis Crick Institute
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APC moonlights to prevent wnt signalosome assembly

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journal contribution
posted on 2021-08-17, 11:01 authored by IJ McGough, JP Vincent
The scaffold protein APC has a well-known function in ensuring β-catenin destruction. In this issue of Developmental Cell, Saito-Diaz et al. (2018) uncover another role for APC in Wnt signaling: to prevent clathrin-dependent signalosome formation in the absence of ligand.