Transcribe this way Rap1 confers promoter directionality by repressing divergent transcription.pdf (1.5 MB)

Transcribe this way: Rap1 confers promoter directionality by repressing divergent transcription.

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journal contribution
posted on 11.11.2020, 13:50 by Andrew CK Wu, Folkert J Van Werven
In eukaryotes, divergent transcription is a major source of noncoding RNAs. Recent studies have uncovered that in yeast, the transcription factor Rap1 restricts transcription in the divergent direction and thereby controls promoter directionality. Here, we summarize these findings, propose regulatory principles, and discuss the implications for eukaryotic gene regulation.

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Crick (Grant ID: 10203, Grant title: van Werven FC001203)

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