Antimicrobial Agents and Chemotherapy-2020-Loiseau-e00782-20.full.pdf (1.12 MB)

HIV coinfection is associated with low-fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis.

Download (1.12 MB)
journal contribution
posted on 09.10.2020 by Chloé Loiseau, Daniela Brites, Miriam Reinhard, Kathrin Zürcher, Sonia Borrell, Marie Ballif, Lukas Fenner, Helen Cox, Liliana K Rutaihwa, Robert J Wilkinson, Marcel Yotebieng, E Jane Carter, Alash'le Abimiku, Olivier Marcy, Eduardo Gotuzzo, Anchalee Avihingsanon, Nicola Zetola, Basra Doulla, Erik C Böttger, Matthias Egger, Sebastien Gagneux
We analysed 312 drug-resistant genomes of Mycobacterium tuberculosis (Mtb) collected from HIV coinfected and HIV negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant Mtb strains isolated from HIV coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low fitness rpoB variants can thrive in the context of reduced host immunity.

Funding

Crick (Grant ID: 10218, Grant title: Wilkinson, R FC001218)

History

Licence

Exports