GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2 GM130.pdf (1.09 MB)

GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130

Download (1.09 MB)
journal contribution
posted on 05.08.2020, 17:11 by Justin Joachim, Sharon A Tooze
WAC and GOLGA2/GM130 are 2 Golgi proteins that affect autophagy; however, their mechanism of action was unknown. We have shown that WAC binding to GOLGA2 at the Golgi displaces GABARAP from GOLGA2 to allow the maintenance of a nonlipidated centrosomal GABARAP pool. Centrosomal GABARAP can traffic to autophagic structures during starvation. In addition GABARAP specifically promotes ULK1 activation and this is independent of GABARAP lipidation but likely requires a LIR-mediated GABARAP-ULK1 interaction.

History

Licence

Exports