Flow cytometry to assess cerebrospinal fluid fungal burden in cryptococcal meningitis
journal contributionposted on 01.10.2020 by James E Scriven, Lisa M Graham, Charlotte Schutz, Thomas J Scriba, Robert J Wilkinson, David R Boulware, Graeme Meintjes, David G Lalloo, Britta C Urban
Any type of content formally published in an academic journal, usually following a peer-review process.
Fungal burden in the cerebrospinal fluid is an important determinant of mortality in cryptococcal meningitis, but its use in aiding clinical decision making is hampered by the time involved to perform quantitative cultures. Here, we demonstrate the potential of flow cytometry as a novel and rapid technique to address this issue.