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Caught in the act: structural dynamics of replication origin activation and fork progression.

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journal contribution
posted on 14.05.2020 by Jacob S Lewis, Alessandro Costa
This review discusses recent advances in single-particle cryo-EM and single-molecule approaches used to visualise eukaryotic DNA replication reactions reconstituted in vitro. We comment on the new challenges facing structural biologists, as they turn to describing the dynamic cascade of events that lead to replication origin activation and fork progression.

Funding

Crick (Grant ID: 10065, Grant title: Costa FC001065) European Research Council (Grant ID: 820102 - CRYOREP, Grant title: ERC 820102 - CRYOREP)

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