Caught in the act: structural dynamics of replication origin activation and fork progression.
journal contributionposted on 14.05.2020 by Jacob S Lewis, Alessandro Costa
Any type of content formally published in an academic journal, usually following a peer-review process.
This review discusses recent advances in single-particle cryo-EM and single-molecule approaches used to visualise eukaryotic DNA replication reactions reconstituted in vitro. We comment on the new challenges facing structural biologists, as they turn to describing the dynamic cascade of events that lead to replication origin activation and fork progression.