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Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein.

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posted on 26.10.2020, 09:30 by Antoni G Wrobel, Donald J Benton, Saira Hussain, Ruth Harvey, Stephen R Martin, Chloë Roustan, Peter B Rosenthal, John J Skehel, Steven J Gamblin
The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.

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Crick (Grant ID: 10143, Grant title: Rosenthal FC001143) Crick (Grant ID: 10078, Grant title: Gamblin FC001078) Crick (Grant ID: 10030, Grant title: McCauley FC001030)

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