A systematic genetic screen identifies essential factors involved in nuclear size control
journal contributionposted on 11.12.2019 by Helena Cantwell, Paul Nurse
Any type of content formally published in an academic journal, usually following a peer-review process.
Nuclear size correlates with cell size, but the mechanism by which this scaling is achieved is not known. Here we screen fission yeast gene deletion mutants to identify essential factors involved in this process. Our screen has identified 25 essential factors that alter nuclear size, and our analysis has implicated RNA processing and LINC complexes in nuclear size control. This study has revealed lower and more extreme higher nuclear size phenotypes and has identified global cellular processes and specific structural nuclear components important for nuclear size control.