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Figure 1B (flipped).tif (5.07 MB)
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Figure 1D (gel 2).tif (11 MB)
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Figure 3C (Gel 1) Figure 6A (Gel2).tif (11 MB)
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Figure 3C part 2.tif (11 MB)
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Figure 3E (gel 2) .tif (11 MB)
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Figure 6A Q_VD_Oph (part 1) & S2B Fatostatin HBr (part 2).tif (11 MB)
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Figure S2A & S2B Shikonin & Tyrphostin AG 1296 (gel 2).tif (11 MB)
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Figure S2B PDK1.tif (11 MB)
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Figure_5_7_S4_S5_FMK_A.png (1.66 MB)
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Figure_5_7_S4_S5_FMK_G.png (843.51 kB)
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Figure_5_7_S4_S5_FMK_R.png (1.28 MB)
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Figure_5_7_S4_S5_FMK+Rem_A.png (1.45 MB)
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Figure_5_7_S4_S5_FMK+Rem_G.png (366.68 kB)
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Figure_5_7_S4_S5_FMK+Rem_R.png (1.27 MB)
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Figure_5_S4_Calpain-+Rem_A.png (1.42 MB)
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Figure_5_S4_Calpain-+Rem_B.png (1.21 MB)
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Figure_5_S4_Calpain-+Rem_G.png (329.69 kB)
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Primary Screen 0.8uM.xlsx (661.91 kB)
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Primary Screen 4uM.xlsx (836.35 kB)
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Library list_Z-score_rank_comments.xlsx (292.71 kB)
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Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp5 Main Protease
dataset
posted on 2021-07-05, 13:20 authored by Jennifer MilliganJennifer Milligan, Theresa ZeisnerTheresa Zeisner, George PapageorgiouGeorge Papageorgiou, Dhira JoshiDhira Joshi, Christelle SoudyChristelle Soudy, Rachel UlfertsRachel Ulferts, Mary WuMary Wu, Chew Theng LimChew Theng Lim, Kang Wei TanKang Wei Tan, Florian WeissmannFlorian Weissmann, Berta CanalBerta Canal, Ryosuke Fujisawa, Tom D Deegan, Hemavathi NagarajHemavathi Nagaraj, Ganka Bineva-ToddGanka Bineva-Todd, Clovis Basier, Joseph CurranJoseph Curran, Michael HowellMichael Howell, Rupert BealeRupert Beale, Karim Labib, Nicola O'ReillyNicola O'Reilly, John DiffleyJohn DiffleyThis entry contains datasets and raw images associated to the following manuscript: “Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp5 Main Protease” Milligan et al., Biochem Journal, 2021
Data files are labelled accordingly to the different Figures and Supplementary figures of the manuscript and include:
Screen data of the raw results of the two screens at both concentrations, the normalised results with z-score, and the plate distribution. See manuscript for further information.
Gel and microscopy images.
Summary data and plots for all IC50 calculations.
Km data and plots.
