This entry contains datasets and raw images associated to the following manuscript: "Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp3 Papain-like Protease", Lim et al., Biochemical Journal, 2021.<div><br></div><div>Data files are labelled accordingly to the different Figures or Supplementary figures of the manuscript and include:</div><div><br></div><div>-Screen data of raw results of two screens at both concentration-high and low</div><div>-Script used to analyse the data of the screen</div><div>-Gel images</div>