DATASET
Corrected_Velocity_analysis_1.25 µM.xlsx (21.29 MB)
DATASET
Corrected_Velocity_analysis_6.25 µM.xlsx (729.39 kB)
DATASET
Endpoint_analysis_6.25 µM.xlsx (24.78 MB)
DOCUMENT
Kinetic curves of selected compounds at 6.25 µM .pdf (46.95 MB)
DATASET
HTS_FullChemicalLibraryV6.xlsx (3.22 MB)
IMAGE
20210126 nsp13, Figure 4G.tif (11 MB)
.GEL
Sup Fig 1G Nsp13-[Phosphor].gel (22.89 MB)
.GEL
Sup Fig 2C Nsp13 on 2-[Phosphor].gel (14.31 MB)
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Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp13 Helicase
dataset
posted on 2021-07-05, 13:18 authored by Agustina BertolinAgustina Bertolin, Florian WeissmannFlorian Weissmann, Jingkun Zeng, John DiffleyJohn DiffleyThis entry contains screen datasets and raw images associated to the following manuscript: "Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp13 Helicase", Zeng et al, Biochem Journal, 2021
The Data include:
-Excel files with description of the chemical library and reaction velocity and endpoint analysis of screen results obtained in the screen to identify inhibitors of nsp13 helicase of SARS-CoV-2. Please see Material and methods, Data analysis.
We also added for each selected compound the kinetic curves of the selected compounds (red) + compounds in the adjacent wells (black).
-Raw gel images (Fig 4G, Supp Fig 1C, Supp Fig 2C)
