Esmail, Hanif Lai, Rachel P Lesosky, Maia Wilkinson, Katalin A Graham, Christine M Coussens, Anna K Oni, Tolu Warwick, James M Said-Hartley, Qonita Koegelenberg, Coenraad F Walzl, Gerhard Flynn, JoAnne L Young, Douglas B Barry, Clifton E O'Garra, Anne Wilkinson, Robert J Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-ᴅ-glucose positron emission and computed tomography Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression. Adult;Coinfection;Disease Progression;Female;Fluorodeoxyglucose F18;HIV Infections;Humans;Interferon-gamma Release Tests;Latent Tuberculosis;Male;Mycobacterium tuberculosis;Positron Emission Tomography Computed Tomography;Radiography, Thoracic;Radiopharmaceuticals;South Africa;Sputum;Tuberculosis;Tuberculosis, Pulmonary;O'Garra FC001126;Wilkinson, R FC001218;Young FC001222;11 Medical and Health Sciences;Immunology 2020-07-27
    https://crick.figshare.com/articles/journal_contribution/Characterization_of_progressive_HIV-associated_tuberculosis_using_2-deoxy-2-_18F_fluoro-_-glucose_positron_emission_and_computed_tomography/12675110