10779/crick.12472715.v1 Stefano De Tito Stefano De Tito Javier H Hervás Javier H Hervás Alexander R van Vliet Alexander R van Vliet Sharon A Tooze Sharon A Tooze The Golgi as an assembly line to the autophagosome. The Francis Crick Institute 2020 ATG9A BAR domain Golgi complex PI(4)P adaptor complexes autophagy Tooze FC001187 Developmental Biology 03 Chemical Sciences 06 Biological Sciences 11 Medical and Health Sciences 2020-06-25 14:00:15 Journal contribution https://crick.figshare.com/articles/journal_contribution/The_Golgi_as_an_assembly_line_to_the_autophagosome_/12472715 Autophagy is traditionally depicted as a signaling cascade that culminates in the formation of an autophagosome that degrades cellular cargo. However, recent studies have identified myriad pathways and cellular organelles underlying the autophagy process, be it as signaling platforms or through the contribution of proteins and lipids. The Golgi complex is recognized as being a central transport hub in the cell, with a critical role in endocytic trafficking and endoplasmic reticulum (ER) to plasma membrane (PM) transport. However, the Golgi is also an important site of key autophagy regulators, including the protein autophagy-related (ATG)-9A and the lipid, phosphatidylinositol-4-phosphate [PI(4)P]. In this review, we highlight the central function of this organelle in autophagy as a transport hub supplying various components of autophagosome formation.