10779/crick.12472715.v1
Stefano De Tito
Stefano
De Tito
Javier H Hervás
Javier H
Hervás
Alexander R van Vliet
Alexander R
van Vliet
Sharon A Tooze
Sharon A
Tooze
The Golgi as an assembly line to the autophagosome.
The Francis Crick Institute
2020
ATG9A
BAR domain
Golgi complex
PI(4)P
adaptor complexes
autophagy
Tooze FC001187
Developmental Biology
03 Chemical Sciences
06 Biological Sciences
11 Medical and Health Sciences
2020-06-25 14:00:15
Journal contribution
https://crick.figshare.com/articles/journal_contribution/The_Golgi_as_an_assembly_line_to_the_autophagosome_/12472715
Autophagy is traditionally depicted as a signaling cascade that culminates in the formation of an autophagosome that degrades cellular cargo. However, recent studies have identified myriad pathways and cellular organelles underlying the autophagy process, be it as signaling platforms or through the contribution of proteins and lipids. The Golgi complex is recognized as being a central transport hub in the cell, with a critical role in endocytic trafficking and endoplasmic reticulum (ER) to plasma membrane (PM) transport. However, the Golgi is also an important site of key autophagy regulators, including the protein autophagy-related (ATG)-9A and the lipid, phosphatidylinositol-4-phosphate [PI(4)P]. In this review, we highlight the central function of this organelle in autophagy as a transport hub supplying various components of autophagosome formation.