%0 Journal Article %A Loveday, Chey %A Litchfield, Kevin %A Proszek, Paula Z %A Cornish, Alex J %A Santo, Flavia %A Levy, Max %A Macintyre, Geoff %A Holryod, Amy %A Broderick, Peter %A Dudakia, Darshna %A Benton, Barbara %A Bakir, Maise Al %A Hiley, Crispin %A Grist, Emily %A Swanton, Charles %A Huddart, Robert %A Powles, Tom %A Chowdhury, Simon %A Shipley, Janet %A O'Connor, Simon %A Brenton, James D %A Reid, Alison %A de Castro, David Gonzalez %A Houlston, Richard S %A Turnbull, Clare %D 2020 %T Genomic landscape of platinum resistant and sensitive testicular cancers. %U https://crick.figshare.com/articles/journal_contribution/Genomic_landscape_of_platinum_resistant_and_sensitive_testicular_cancers_/12302252 %2 https://crick.figshare.com/ndownloader/files/22678211 %K Swanton FC001169 %X While most testicular germ cell tumours (TGCTs) exhibit exquisite sensitivity to platinum chemotherapy, ~10% are platinum resistant. To gain insight into the underlying mechanisms, we undertake whole exome sequencing and copy number analysis in 40 tumours from 26 cases with platinum-resistant TGCT, and combine this with published genomic data on an additional 624 TGCTs. We integrate analyses for driver mutations, mutational burden, global, arm-level and focal copy number (CN) events, and SNV and CN signatures. Albeit preliminary and observational in nature, these analyses provide support for a possible mechanistic link between early driver mutations in RAS and KIT and the widespread copy number events by which TGCT is characterised. %I The Francis Crick Institute