p53, cancer and the immune response. Julianna Blagih Michael D Buck Karen H Vousden 10779/crick.11955903.v1 https://crick.figshare.com/articles/journal_contribution/p53_cancer_and_the_immune_response_/11955903 The importance of cancer-cell-autonomous functions of the tumour suppressor p53 (encoded by TP53) has been established in many studies, but it is now clear that the p53 status of the cancer cell also has a profound impact on the immune response. Loss or mutation of p53 in cancers can affect the recruitment and activity of myeloid and T cells, allowing immune evasion and promoting cancer progression. p53 can also function in immune cells, resulting in various outcomes that can impede or support tumour development. Understanding the role of p53 in tumour and immune cells will help in the development of therapeutic approaches that can harness the differential p53 status of cancers compared with most normal tissue. 2020-04-17 10:55:54 Cancer Immune response p53 Vousden FC001557 Developmental Biology 06 Biological Sciences 11 Medical and Health Sciences