Cardoso-Moreira, Margarida Halbert, Jean Valloton, Delphine Velten, Britta Chen, Chunyan Shao, Yi Liechti, Angélica Ascenção, Kelly Rummel, Coralie Ovchinnikova, Svetlana Mazin, Pavel V Xenarios, Ioannis Harshman, Keith Mort, Matthew Cooper, David N Sandi, Carmen Soares, Michael J Ferreira, Paula G Afonso, Sandra Carneiro, Miguel Turner, James MA VandeBerg, John L Fallahshahroudi, Amir Jensen, Per Behr, Rüdiger Lisgo, Steven Lindsay, Susan Khaitovich, Philipp Huber, Wolfgang Baker, Julie Anders, Simon Zhang, Yong E Kaessmann, Henrik Gene expression across mammalian organ development. The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early organogenesis to adulthood for human, rhesus macaque, mouse, rat, rabbit, opossum and chicken. Comparisons of gene expression patterns identified correspondences of developmental stages across species, and differences in the timing of key events during the development of the gonads. We found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase. We identified differences in the temporal trajectories of expression of individual genes across species, with brain tissues showing the smallest percentage of trajectory changes, and the liver and testis showing the largest. Our work provides a resource of developmental transcriptomes of seven organs across seven species, and comparative analyses that characterize the development and evolution of mammalian organs. Animals;Biological Evolution;Chickens;Female;Gene Expression Regulation, Developmental;Humans;Macaca mulatta;Male;Mice;Opossums;Organogenesis;Rabbits;Rats;Transcriptome;Turner FC001193;General Science & Technology 2020-01-09
    https://crick.figshare.com/articles/journal_contribution/Gene_expression_across_mammalian_organ_development_/11558463