Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration
Alessandro PristerÃ
Craig Blomeley
Emanuel Lopes
Sarah Threlfell
Elisa Merlini
Denis Burdakov
Stephanie Cragg
François Guillemot
Siew-Lan Ang
10779/crick.11409375.v1
https://crick.figshare.com/articles/journal_contribution/Dopamine_neuron-derived_IGF-1_controls_dopamine_neuron_firing_skill_learning_and_exploration/11409375
Midbrain dopamine neurons, which can be regulated by neuropeptides and hormones, play a fundamental role in controlling cognitive processes, reward mechanisms, and motor functions. The hormonal actions of insulin-like growth factor 1 (IGF-1) produced by the liver have been well described, but the role of neuronally derived IGF-1 remains largely unexplored. We discovered that dopamine neurons secrete IGF-1 from the cell bodies following depolarization, and that IGF-1 controls release of dopamine in the ventral midbrain. In addition, conditional deletion of dopamine neuron-derived IGF-1 in adult mice leads to decrease of dopamine content in the striatum and deficits in dopamine neuron firing and causes reduced spontaneous locomotion and impairments in explorative and learning behaviors. These data identify that dopamine neuron-derived IGF-1 acts as a regulator of dopamine neurons and regulates dopamine-mediated behaviors.
2019-12-19 18:08:48
IGF-1
behavior
dopamine
firing
somatodendritic
Animals
Cognition
Corpus Striatum
Dopaminergic Neurons
Exploratory Behavior
Hormones
Insulin-Like Growth Factor I
Learning
Locomotion
Mesencephalon
Mice
Neuropeptides
Guillemot FC001089
Burdakov FC001055