%0 Journal Article %A Li, Yifan Joshua %A Wilkinson, Katalin A %A Wilkinson, Robert J %A Figaji, Anthony A %A Rohlwink, Ursula K %D 2019 %T Elevated matrix metalloproteinase concentrations offer novel insight into their role in pediatric tuberculous meningitis %U https://crick.figshare.com/articles/journal_contribution/Elevated_matrix_metalloproteinase_concentrations_offer_novel_insight_into_their_role_in_pediatric_tuberculous_meningitis/11371977 %2 https://crick.figshare.com/ndownloader/files/20202759 %K Wilkinson, R FC001218 %X We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors. The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1), and TIMP-2 were significantly elevated in the lumbar CSF samples, and we found interesting dynamics for MMP-9 that offer novel insight into its role in pediatric patients with tuberculous meningitis. %I The Francis Crick Institute