10779/crick.11371977.v1
Yifan Joshua Li
Yifan Joshua
Li
Katalin A Wilkinson
Katalin A
Wilkinson
Robert J Wilkinson
Robert J
Wilkinson
Anthony A Figaji
Anthony A
Figaji
Ursula K Rohlwink
Ursula K
Rohlwink
Elevated matrix metalloproteinase concentrations offer novel insight into their role in pediatric tuberculous meningitis
The Francis Crick Institute
2019
Wilkinson, R FC001218
2019-12-16 17:36:28
Journal contribution
https://crick.figshare.com/articles/journal_contribution/Elevated_matrix_metalloproteinase_concentrations_offer_novel_insight_into_their_role_in_pediatric_tuberculous_meningitis/11371977
We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors. The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1), and TIMP-2 were significantly elevated in the lumbar CSF samples, and we found interesting dynamics for MMP-9 that offer novel insight into its role in pediatric patients with tuberculous meningitis.