Repeated clinical malaria episodes are associated with modification of the immune system in children
Yaw Bediako
Rhys Adams
Adam J Reid
John Joseph Valletta
Francis M Ndungu
Jan Sodenkamp
Jedidah Mwacharo
Joyce Mwongeli Ngoi
Domtila Kimani
Oscar Kai
Juliana Wambua
George Nyangweso
Etienne P de Villiers
Mandy Sanders
Magda Ewa Lotkowska
Jing-Wen Lin
Sarah Manni
John WG Addy
Mario Recker
Chris Newbold
Matthew Berriman
Philip Bejon
Kevin Marsh
Jean Langhorne
10779/crick.11353592.v1
https://crick.figshare.com/articles/journal_contribution/Repeated_clinical_malaria_episodes_are_associated_with_modification_of_the_immune_system_in_children/11353592
There are over 200 million reported cases of malaria each year, and most children living in endemic areas will experience multiple episodes of clinical disease before puberty. We set out to understand how frequent clinical malaria, which elicits a strong inflammatory response, affects the immune system and whether these modifications are observable in the absence of detectable parasitaemia.
2019-12-11 16:08:44
Immune activation
Malaria
Systems immunology
Child
Child, Preschool
Humans
Immune System Diseases
Langhorne FC001101
General & Internal Medicine
11 Medical and Health Sciences